Heart Disease Masterclass - Tom Dayspring, M.D. – Part 3: Cholesterol Lowering Medication

In this series, Dr Thomas 'Tom' Dayspring, M.D., one of the world's most recognised experts in lipidology, shares his breadth of knowledge on heart disease prevention.

Part 3 covers the types of cholesterol lowering medication, as well as testing for hyper absorbers of cholesterol.

Plenty of Tom's personal illustrations, diagrams & graphics included. You can test your knowledge by having a go at the quiz below. 

00:00 Intro 04:58 Cholesterol absorption in gut  06:22 Fecal excretion of cholesterol  06:54 Sterols & xenosterols  09:41 Niemann-Pick C1-Like 1 Protein & ATP-binding cassette transporter G5/G8   11:23 Synergy between NPC1L1 & ATP-binding cassette transporter G5/G8     12:47 Hyper absorption of cholesterol  13:19 Ezetimibe  14:09 Free cholesterol & cholesterol ester  16:13 CD36 Receptor for fatty acids  16:35 Cholesterol of hepatobiliary origin  18:15 Is dietary cholesterol a risk factor  ?  18:50 Tests for hyper absorbers & phytosterols  20:02 Ezetimibe for hyper absorbers  21:27 Stanols, gut bacteria & benecol   24:59 Excess cholesterol within HDL particles in hyper absorbers  27:35 Ezetimibe as an add-on or first-line therapy  28:38 The failure of niacin & fibrates  29:27 Statins & the inhibition of cholesterol synthesis  30:35 Potential downsides to statins  34:23 Bempedoic acid  37:50 PCSK9 inhibitors for nightmare ApoB  45:56 Inclisiran PCSK9 (Leqvio)  47:24 Lipoprotein(a)  51:10 Outro  

Interactive quiz:  https://forms.office.com/Pages/ResponsePage.aspx?id=jM-h1o52h0GnOLblDE3rStdKkvg0Y_NMm65uD3dzrKpUNFFYNjZSTjZKUkRYNUVZWUpGMUw2RTIzSi4u  Give Tom a follow on Twitter: https://twitter.com/Drlipid

Give Tom a follow on Twitter: https://twitter.com/Drlipid

Other appearances from Tom: 

Drive Podcast 

https://www.youtube.com/watch?v=PllTHYgWpuwWellness: 

Fact vs. Fiction 

https://podcasts.apple.com/us/podcast/a-masterclass-in-cholesterol-and-lipid-lowering/id1447250475?i=1000581954971

Nutrition Made Simple 

lp(a): https://www.youtube.com/watch?v=-WRRyG8il4g

Dietary cholesterol: https://www.youtube.com/watch?v=GkWMDnTyxfo

Coronary Calcium Score (CAC): https://www.youtube.com/watch?v=gxIeRUbHauw 

Narrative glossary on lipids provided by Tom: https://peterattiamd.com/glossary-lipids/

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Welcome to the Foolproof Mastery Podcast.

I’m Patrick Raizerov, and this is the space for people who are curious about everything. At Foolproof Mastery, we let the facts and knowledge do the talking, whilst teaching you how to become the best version of yourself through a vegan lifestyle.

We have regular interviews with top experts, scientists, athletes and many more inspirational people, with some humour occasionally thrown into the mix.

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• No. of episodes: 31
• Latest episode: 2024-05-22
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